Selected Publications
* equal contribution, § co-corresponding authors
2024
Constitutive activation mechanism of a class C GPCR
Jinwoo Shin*, Junhyeon Park*, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V. Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim§, Yunje Cho§
Nature Structural & Molecular Biology (2024) Feb 8. doi: https://doi.org/10.1038/s41594-024-01224-7
2023
Structural mechanism of Escherichia coli cyanase
Jihan Kim, Youngchang Kim, Jaehyun Park, Ki Hyun Nam§, Yunje Cho§
Acta Crystallographica Section D (2023) Nov 2. doi: https://doi.org/10.1107/S2059798323009609
A stepwise activation model for the insulin receptor
Na-Oh Yunn§, Junhong Kim, Sung Ho Ryu, Yunje Cho§
Experimental & Molecular Medicine (2023) Oct 2. doi: https://doi.org/10.1038/s12276-023-01101-1
2022
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung§, Yunje Cho§
Nature Communications (2022) Nov 8. doi: https://doi.org/10.1038/s41467-022-34612-y
Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Junhong Kim*, Na-Oh Yunn*§, Mangeun Park, Jihan Kim, Seongeun Park, Yoojoong Kim, Jeongeun Noh, Sung Ho Ryu§, Yunje Cho§
Nature Communications (2022) Oct 30. doi: https://doi.org/10.1038/s41467-022-34292-8
Structure of the Human TELO2-TTI1-TTI2 Complex
Youngran Kim*, Junhyeon Park*, So Young Joo, Byung-Gyu Kim, Aera Jo, Hyunsook Lee, Yunje Cho
Journal of Molecular Biology (2022) Jan 30. doi: https://doi.org/10.1016/j.jmb.2021.167370
2021
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
Eunyoung Jeong*, Yoojoong Kim*, Jihong Jeong, Yunje Cho
Nature Communications (2021) Nov 23. doi: https://doi.org/10.1038/s41467-021-27147-1
Structure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex
Aera Jo, Shibai Li, Jinwoo Shin, Xiaolan Zhao, Yunje Cho
Journal of Molecular Biology (2021) April 30. doi: https://doi.org/10.1016/j.jmb.2021.166910
2020
Structural Basis for Activation of the Heterodimeric GABAB receptor
Yoojoong Kim, Eunyoung Jeong, Ji-hong Jeong, Youngjin Kim, Yunje Cho
Journal of Molecular Biology (2020) Nov 6. doi: https://doi.org/10.1016/j.jmb.2020.09.023
Structural Basis for the Antibiotic Resistance of Eukaryotic Isoleucyl-tRNA Synthetase
Scisung Chung, Sulhee Kim, Sung Ho Ryu, Kwang Yeon Hwang, Yunje Cho
Molecules and Cells (2020) Apr 30. doi: https://doi.org/10.14348/molcells.2020.2287
Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex
Eunyoung Jeong, Seong-Gyu Lee, Hyun-Suk Kim, Jihyeon Yang, Jinwoo Shin, Youngran Kim, Jihan Kim, Orlando D Schärer, Youngjin Kim, Jung-Eun Yeo, Ho Min Kim, Yunje Cho
Nucleic Acids Research (2020) Apr 6. doi: https://doi.org/10.1093/nar/gkaa062
2018
Structural Mechanism of DNA Interstrand Cross-link Unhooking by Bacterial FAN1 Nuclease
Hyeonseok Jin, Upasana Roy, Gwangrog Lee, Orlando D. Schärer, Yunje Cho
Journal of Biological Chemistry (2018) Apr 27. doi: https://doi.org/10.1074/jbc.RA118.002171
2017
Structural and Functional Relationships of FAN1
Hyeonseok Jin, Yunje Cho
DNA Repair (2017) Aug 27. doi: https://doi.org/10.1016/j.dnarep.2017.06.016
Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing
Jin S. Kim, Michael T. Nanfara, Sundari Chodavarapu, Kyeong S. Jin, Vignesh M. P. Babu, Mohamed A. Ghazy, Scisung Chung, Jon M. Kaguni, Mark D. Sutton, Yunje Cho
Nucleic Acids Research (2017) Apr 20. doi: https://doi.org/10.1093/nar/gkx081
Eukaryotic Rad50 functions as a rod-shaped dimer
Young Bong Park*, Marcel Hohl*, Michał Padjasek, Eunyoung Jeong, Kyeong Sik Jin, Artur Krężel, John H J Petrini§, Yunje Cho§
Nature Structural & Molecular Biology (2017) Jan 30. doi: https://doi.org/10.1038/nsmb.3369
2016
ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
Yaqi Liu*, Sihyun Sung*, Youngran Kim*, Fuyang Li, Gwanghyun Gwon, Aera Jo, Ae-Kyoung Kim, Taeyoon Kim, Ok-kyu Song, Sang Eun Lee, Yunje Cho
EMBO Journal (2016) Apr 1. doi: https://doi.org/10.15252/embj.201592462
2015
Crystal structure of the Rad3/XPD regulatory domain of Ssl1/p44
Jin Seok Kim*, Charlotte Saint-André*, Hye Seong Lim, Cheol-Sang Hwang, Jean Marc Egly§, Yunje Cho§
Journal of Biological Chemistry (2015) April 1. doi: https://doi.org/10.1074/jbc.M115.636514
2014
Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation
Yaoyao Fu*, Youngran Kim*, Kyeong Sik Jin, Hyun Sook Kim, Jong Hyun Kim, DongMing Wang, Minyoung Park, Chang Hwa Jo, Nam Hoon Kwon, Doyeun Kim, Myung Hee Kim, Young Ho Jeon, Kwang Yeon Hwang§, Sunghoon Kim, Yunje Cho§
Proceedings of the National Academy of the Sciences (2014) Oct 21. doi: https://doi.org/10.1073/pnas.1408836111
Dae Heon Kim, Mi-Jeong Park, Gwang Hyeon Gwon, Antonina Silkov, Zheng-Yi Xu, Eun Chan Yang, Seohyeon Song, Kyungyoung Song, Younghyun Kim, Hwan Su Yoon, Barry Honig, Wonhwa Cho§, Yunje Cho§, Inhwan Hwang§
Developmental Cell (2014) Sep 8. doi: https://doi.org/10.1016/j.devcel.2014.07.026
DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA
Sihyun Sung*, Fuyang Li*, Young Bong Park, Jin Seok Kim, Ae-Kyoung Kim, Ok-kyu Song, Jiae Kim, Jun Che, Sang Eun Lee§, Yunje Cho§
EMBO Journal (2014) Oct 16. doi: https://doi.org/10.15252/embj.201488299
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates
Gwang Hyeon Gwon, Aera Jo, Kyuwon Baek, Kyeong Sik Jin, Yaoyao Fu, Jong-Bong Lee, Youngchang Kim, Yunje Cho
EMBO Journal (2014) May 1. doi: https://doi.org/10.1002/embj.201487820
Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
Gwang Hyeon Gwon*, Youngran Kim*, Yaqi Liu*, Adam T Watson, Aera Jo, Thomas J Etheridge, Fenghua Yuan, Yanbin Zhang, YoungChang Kim, Anthony M Carr, Yunje Cho
Genes & Development (2014) Oct 15. doi: https:/doi.org/10.1101/gad.248492.114
(Cover Article: Volume 28 No. 20 in Oct 15, 2014)
2012
Crystal structure of the NurA–dAMP–Mn2+ complex
Jina Chae, Young Chang Kim, Yunje Cho
Nucleic Acids Research (2012) Mar 1. doi: https://doi.org/10.1093/nar/gkr999
2011
Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations
Young Bong Park, Jina Chae, Young Chang Kim, Yunje Cho
Structure (2011) Nov 9. doi: https://doi.org/10.1016/j.str.2011.09.010
Hye Seong Lim*, Jin Seok Kim*, Young Bong Park, Gwang Hyeon Gwon, Yunje Cho
Genes & Development (2011) May 15. doi: http://doi.org/10.1101/gad.2037811
2009
Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors
Bulat I Khayrutdinov*, Won Jin Bae*, Young Mi Yun*, Jie Hye Lee, Takashi Tsuyama, Jung Joo Kim, Eunha Hwang, Kyoung-Seok Ryu, Hae-Kap Cheong, Chaejoon Cheong, Jung-Soon Ko, Takemi Enomoto, P Andrew Karplus, Peter Güntert, Shusuke Tada, Young Ho Jeon§, Yunje Cho§
Protein Science (2009) Nov 18. doi: https://doi.org/10.1002/pro.236
Crystal structure of the human rad9-hus1-rad1 clamp
Sun Young Sohn, Yunje Cho
Journal of Molecular Biology (2009) Jul 17. doi: https://doi.org/10.1016/j.jmb.2009.05.028
Crystal structure of the eIF4A-PDCD4 complex
Jeong Ho Chang, Yong Hyun Cho, Sun Young Sohn, Jung Min Choi, Ahreum Kim, Young Chang Kim, Sung Key Jang, Yunje Cho
Proceedings of the National Academy of the Sciences (2009)
Mar 3. doi: https://doi.org/10.1073/pnas.0808275106
2008
Crystal structure of the Mus81-Eme1 complex
Jeong Ho Chang, Jeong Joo Kim, Jung Min Choi, Jung Hoon Lee, Yunje Cho
Genes & Development (2008) Apr 15. doi: https://doi.org/10.1101/gad.1618708
2007
Crystal structure of human DGCR8 core
Sun Young Sohn, Won Jin Bae, Jeong Joo Kim, Kyu-Hyeon Yeom, V Narry Kim, Yunje Cho
Nature Structural & Molecular Biology (2007) Sep 14. doi: https://doi.org/10.1038/nsmb1294
Crystal structure of the human GINS complex
Jung Min Choi, Hye Seong Lim, Jeong Joo Kim, Ok-Kyu Song, Yunje Cho
Genes & Development (2007) Jun 1. doi: https://doi.org/10.1101/gad.1548107
Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein
Jung Min Choi, Sung Yun Kang, Won Jin Bae, Kyeong Sik Jin, Moonhor Ree, Yunje Cho
Journal of Biological Chemistry (2007) Mar 30. doi: https://doi.org/10.1074/jbc.M609657200
2005
Structure of a peptide:N-glycanase-Rad23 complex: insight into the deglycosylation for denatured glycoproteins
Jung-Hoon Lee, Jung Min Choi, Changwook Lee, Ki Joung Yi, Yunje Cho
Proceedings of the National Academy of the Sciences (2005) Jun 28. doi: https://doi.org/10.1073/pnas.0502082102
2004
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Changwook Lee, BumSoo Hong, Jung Min Choi, Yugene Kim, Saori Watanabe, Yukio Ishimi, Takemi Enomoto, Shusuke Tada, Youngchang Kim, Yunje Cho
Nature (2004) Aug 19. doi: https://doi.org/10.1038/nature02813
Probing the functional importance of the hexameric ring structure of RNase PH
Jung Min Choi, Eun Young Park, Jun Hyun Kim, Sung Key Chang, Yunje Cho
Journal of Biological Chemistry (2004) Jan 2. doi: https://doi.org/10.1074/jbc.M309628200
2003
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet
Taewoo Kwon, Jeong Ho Chang, Eunyee Kwak, Chang Wook Lee, Andrzej Joachimiak, Young Chang Kim, Jaewoon Lee, Yunje Cho
EMBO Journal (2003) Jan 15. doi: https://doi.org/10.1093/emboj/cdg025
2002
Changwook Lee, Jeong Ho Chang, Hyun Sook Lee, Yunje Cho
Genes & Development (2002) Dec 15. doi: https://doi.org/10.1101/gad.1046102